Metaplastic change in the cervix and its physiological basis metaplasia is the name given to the process by which one fully differentiated type of epithelium appears to transform into another differentiated type. Trauma, chronic irritation or cervical infection can stimulate repair and metaplasia or the cause can be iatrogenic cryosurgery etc. Pdf on jan 1, 2011, raquel garzaguajardo and others published cambios morfologicos benignos. Cervical screening is designed to pick up what is called dyskariosis or cervical intraepithelial neoplasia cin, because it is these changes that can eventually develop into cervical cancer. Since the simultaneous disclosure that human papillomavirus hpv was involved in cervical dysplas ias. Metaplasia does not result from a change in the phenotype of a differentiated cell type. Sils are characterized by human papillomavirus hpv positivity and increased cellular proliferation, but these.
Cervical cancer is one of the most frequent conditions among the worldwide female population. Metaplastic change in the cervix and its physiological basis. Ck17 and p16 expression patterns distinguish atypical immature squamous metaplasia from highgrade cervical intraepithelial neoplasia cin iii. Squamous metaplasia of uterine cervix is a benign condition and there is no risk for a malignant transformation. Case reports young woman with postconization hematometra due to endocervical bone metaplasia j low genit tract dis 2014. Metaplasia escamosa 18 100% hiperplasia endocervical 14 78% remanescentes mesonefricos 1 5% neoplasia intraepitelial escamosa ou glandular 11 61% carcinoma epidermoide ou adenocarcinoma 6 33% hiperplasia glandular e microglandular e tunnel clusters. Among more than 100 genotypes, hpv type 16 is the most common type globally and has been implicated in approximately 56% of all cervical cancers 25. Atypical immature metaplasia aim is a poorly characterized cervical lesion with uncertain biological and clinical significance. Aim shares some, but not all, morphological features of squamous intraepithelial lesions sils. Aug 15, 2012 the relationships between cervical ectopy, squamous metaplastic activity, and hpv infection in young women are likely complex. Por fim, a totalidade do epitelio endocervical evertido pode ser substituido por epitelio escamoso. It is a pathological term used to refer to an irregularity that hinders cell maturation within a particular tissue. Human papillomavirus hpv infection, the cause of cervical cancer, is estimated to be the most common sexually transmitted infection sti in the united states. Jan 03, 2019 a metaplasia is defined as the change of one type of epithelium to another type of epithelium.
The biopsy results of women treated with cryotherapy are shown in table 7. As with most stis, hpv rates are highest in younger females 6, 7. E19 44 year old woman with ectocervical epidermoid metaplasia arch pathol lab med 2004. The authors journal compilation histopathologgy, austria, v. Of the women treated, 22% were diagnosed with a cervical lesion of low grade or worse and the majority of cases were determined to be cervicitis, metaplasia, and condiloma or hpv infections. In a metaplastic change, these precursor cells differentiate along a new pathway. Nic, lesion intraepitelial escamosa, p16, condiloma. However, the transformation zone of metaplastic change within the cervix is very vulnerable to human papilloma virus infection, which is. Metaplasia definition of metaplasia by medical dictionary. American cancer society, american society for colposcopy and cervical pathology, and american society for clinical pathology screening guidelines for the prevention and early detection of cervical cancer. A metaplasia is defined as the change of one type of epithelium to another type of epithelium. Alteracao metaplasica na cervix e sua base fisiologica. Young woman with postconization hematometra due to endocervical bone metaplasia j low genit tract dis 2014. Dysplasia comes from the root greek term meaning bad formation.